Tacrolimus

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Também chamado: FK506; TAC
[Often referred to by brand name (see MedlinePlus Drug Information)]
Nome formal: Tacrolimus

De relance

Por que fazer este exame?

To determine the concentration of tacrolimus in the blood in order to establish a dosing regimen, maintain therapeutic levels, and detect toxic levels

Quando fazer este exame?

As soon as tacrolimus therapy begins, frequently at first then at regular intervals to monitor concentrations over time

Amostra:

A blood sample drawn from a vein in your arm

É necessária alguma preparação?

Have the sample collected 12 hours after the last dose and immediately prior to the next dose or as directed by your doctor.

A amostra

O que está sendo pesquisado?

This test measures the amount of tacrolimus in the blood. Tacrolimus is an immunosuppressive drug that is given orally or intravenously to patients who have had a kidney, liver, heart, or other organ transplant. Normally, a person’s immune system would recognize the new organ as foreign and begin to attack it. Tacrolimus limits this response and helps to prevent organ rejection by inhibiting the activation of T-lymphocytes.

Tacrolimus levels in the blood must be maintained within a narrow therapeutic range. If the concentration is too low, organ rejection may occur; if it is too high, then the patient may have symptoms associated with toxicity. Dosages must be tailored to the individual. Often, patients will begin with higher doses of tacrolimus at the start of therapy and then decrease the dose over the next few weeks. Tacrolimus is usually taken twice a day at set intervals before or after meals. When a person takes a dose, blood concentrations rise and peak within about 2 to 3 hours and then begin to slowly drop. The blood test is usually measured as a “trough” level. It is timed so that the collection is 12 hours post dose and/or prior to the next dose – at the drug’s lowest concentration in the blood.

Como a amostra é obtida para o exame?

A blood sample is obtained by inserting a needle into a vein in the arm.

NOTA: Se exames médicos em você ou em alguém importante para você o deixam ansioso ou constrangido, ou se você tem dificuldade de lidar com eles, leia um ou mais dos seguintes artigos: Lidando com dor, desconforto ou ansiedade durante o exame, Conselhos sobre exames de sangue, Conselhos para ajudar crianças durante exames médicos, and Conselhos para ajudar idosos durante exames médicos.

Outro artigo, Siga essa amostra, fornece uma visão da coleta e do processamento de uma amostra de sangue e de uma amostra de cultura da garganta.

É necessário algum preparo para garantir a qualidade da amostra?

Have the sample collected 12 hours after the last dose and immediately prior to the next dose or as directed by your doctor.

O exame

Perguntas frequentes

Pergunte ao laboratório

* indica um campo necessário



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Fontes do artigo

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NOTA: Este artigo se baseia em pesquisas que incluíram as fontes citadas e a experiência coletiva de Lab Tests Online Conselho de Revisão Editorial. Este artigo é submetido a revisões periódicas do Conselho Editorial, e pode ser atualizado como resultado dessas revisões. Novas fontes citadas serão adicionadas à lista e distinguidas das fontes originais usadas.

S1
Clarke, W. and Dufour, D. R., Editors (2006). Contemporary Practice in Clinical Chemistry. AACC Press, Washington, DC. McMillin, G. and Hammett-Stabler, C. Chapter 39: Therapeutic Drug Monitoring, pp 453-463.

S2
(2007 April 1). Tacrolimus [13 paragraphs]. MedlinePlus Drug Information [On-line information]. Accessed on: 6/9/07 Available FTP: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a601117.html

S3
Aradhye, S., et. al. (2006 December, Revised). Medicines for Keeping Your New Kidney Healthy [117 paragraphs]. American Society of Transplantation [On-line information]. Accessed on: 6/9/07 Available FTP: http://www.a-s-t.org/files/pdf/patient_education/english/AST-EdBroKIDNEYMED-ENG.pdf

S4
(2006 July 1, Revised). Tacrolimus Topical [22 paragraphs]. MedlinePlus Drug Information [On-line information]. Accessed on: 6/9/07 Available FTP: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a602020.html

S5
Howard, A. (2004 July 12). Long-Term Monitoring and Care of the Kidney Transplant Recipient [6 paragraphs]. Medscape Transplantation 5(2), 2004 [On-line article]. Accessed on: 6/9/07 Available FTP: http://www.medscape.com/viewarticle/481411

S6
Kim, J. Cyclosporine and Tacrolimus Toxicities [5 paragraphs]. Kidney Transplant Program, Univ of Southern California Department of Surgery [On-line information]. Accessed on: 6/9/07 Available FTP: http://www.kidneytransplant.org/article-cyclosporineandtacrolimustoxicities.html

S7
(© 2007). Tacrolimus [8 paragraphs]. ARUP's Laboratory Test Directory [On-line information]. Accessed on: 6/16/07 Available FTP: http://www.aruplab.com/TestDirectory/clinical_guide.jsp

S8
(© 2007). Tacrolimus [7 paragraphs]. LabCorp's On-line Directory of Services and Interpretive Guide [On-line information]. Accessed on: 6/16/07 Available FTP: http://www.labcorp.com/datasets/labcorp/html/chapter/

S9
(2006 April, Revised). Prograf [139 paragraphs]. FDA MedWatch [On-line information]. Accessed on: 6/16/07 Available FTP: http://www.fda.gov/medwatch/SAFETY/2006/Apr_PIs/Prograf_PI.pdf

S10
(2007 April 1). Tacrolimus (Oral Route, Intravenous Route) [36 paragraphs]. Mayoclinic.com [On-line information]. Accessed on: 6/10/07 Available FTP: http://www.mayoclinic.com/health/drug-information/DR601851

S11
Woo, D. and James, W. (2005 May 24). Topical Tacrolimus: A Review of Its Uses in Dermatology [80 paragraphs]. Medscape from Dermatitis 2005;16(1):6-21 [On-line article]. Accessed on: 6/9/07 Available FTP: http://www.medscape.com/viewarticle/505242

S12
(2001). Therapeutic Drug Monitoring – Is it Important for Newer Immunosuppressive Agents? [22 paragraphs]. Medscape from Drug Ther Perspect 17(22):8-12, 2001 [On-line information]. Accessed on: 6/9/07 Available FTP: http://www.medscape.com/viewarticle/414907

S13
Martindale – The Complete Drug Reference. (Online information, accessed August 2007) Available FTP: http://www.thomsonhc.com/hcs/librarian/PFDefaultActionId/pf.PrintReady